发明名称 |
Protease-resistant thrombomodulin analogs |
摘要 |
The present invention relates to the single-chain thrombomodulin ("TM") and analogs thereof that are not susceptible to cleavage by proteases and retain the biological activity of thrombomodulin, as well as methods of use in, for example, antithrombotic therapy. Novel proteins, nucleic acid gene sequences, pharmaceuticals and methods of inhibiting thrombotic activity are disclosed.
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申请公布号 |
US5827824(A) |
申请公布日期 |
1998.10.27 |
申请号 |
US19950463605 |
申请日期 |
1995.06.05 |
申请人 |
SCHERING AKTIENGESELLSCHAFT |
发明人 |
LIGHT, DAVID RICHARD;ANDREWS, WILLIAM H.;CLARKE, JEFFREY HOMER;WYDRO, ROBERT MICHAEL;YOUNG, PATRICIA ANN |
分类号 |
A61K38/00;C07K14/315;C07K14/745;C12N9/72;C12P21/04;(IPC1-7):A61K38/00;A61K38/16;C07K14/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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地址 |
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