| 摘要 |
Novel 1,3,4,9,10,10a-hexahydro-6-substituted-11-(14-alkyl-acetamido)-2H-10,4a(iminoethano)-phenanthrene derivatives, having following formula (I), wherein: n is zero 1, 2 or 3; each of R and R1, being the same or different, is hydrogen, halogen, hydroxy, trifluoromethyl, cyano, nitro, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, SOR5, SO2R5, SO2NH2, formyl, C2-C6 alkanoyl, carboxy, C1-C6 alkoxy-carbonyl or -N(R6R7) in which each of R6 and R7 independently is hydrogen, C1-C6 alkyl, formyl or C2-C6 alkanoyl and R5 is hydrogen or C1-C6 alkyl; each of R2 and R20, being the same or different, is hydrogen, C1-C6 alkyl unsubstituted or substituted by hydroxy or by a phenyl ring in its turn optionally substituted by 1 to 4 substituents independently chosen from halogen, C1-C6 alkyl, C1-C6 alkoxy and trifluoromethyl; or R2 and R20 taken together with the adjacent carbon atom form a C3-C6 cycloalkyl ring; each of R3 and R4, which are the same or different, is hydrogen or C1-C6 alkyl; and the pharmaceutically acceptable salts thereof, are active on the CNS. |
