发明名称 |
NOVEL LDL-RECEPTOR |
摘要 |
A novel receptor, "LDL-receptor related protein-3" ("LRP-3"), is provided, along with encoding nucleic acid. The gene is associated with type 1 diabetes (insulin dependent diabetes mellitus), and experimental evidence provides indication that it is the IDDM susceptibility gene IDDM4. In various aspects the invention provides nucleic acid, including coding sequences, oligonucleotide primers and probes, polypeptides, pharmaceutical compositions, methods of diagnosis or prognosis, and other methods relating to and based on the gene, including methods of treatment of diseases in which the gene may be implicated, including autoimmune diseases, such as glomerulonephritis, diseases and disorders involving disruption of endocytosis and/or antigen presentation, diseases and disorders involving cytokine clearance and/or inflammation, viral infection, elevation of free fatty acids or hypercholesterolemia, osteoporosis, Alzheimer's disease, and diabetes.
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申请公布号 |
CA2286313(A1) |
申请公布日期 |
1998.10.22 |
申请号 |
CA19982286313 |
申请日期 |
1998.04.15 |
申请人 |
MERCK & CO., INC.;THE WELLCOME TRUST LIMITED AS TRUSTEE TO THE WELCOME TRUST |
发明人 |
TWELLS, REBECCA CHRISTINA JOAN;NAKAGAWA, YUSUKE;METZKER, MICHAEL LEE;HEY, PATRICIA;MERRIMAN, TONY RAYMOND;CASKEY, CHARLES THOMAS;GERHOLD, DAVID;KAWAGUCHI, YOSHIHIKO;PHILLIPS, MICHAEL SEAN;COX, ROGER DAVID;HESS, JOHN WILFRED;TODD, JOHN ANDREW;HAMMOND, HOLLY |
分类号 |
C12N15/09;A61K38/00;A61K39/395;A61K48/00;A61P3/06;A61P3/10;A61P13/12;A61P19/10;A61P25/28;A61P31/12;A61P37/02;A61P43/00;C07K14/705;C07K16/28;C12N15/12;C12Q1/68;(IPC1-7):C12N15/12;C12N15/11;A61K38/17 |
主分类号 |
C12N15/09 |
代理机构 |
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