发明名称 |
Pyrimido[5,4]-dipyrimidines, pharmaceuticals containing them, their use and processes for the preparation thereof |
摘要 |
Pyrimido[5,4-d]pyrimidines of the general formula <IMAGE> (I) which have an inhibitory effect on signal transduction mediated by tyrosine kinases, their use for the treatment of disorders, in particular of oncoses, and their preparation. Exemplary compounds are: 4-[(3-Chloro-4-fluorophenyl)amino]-6-[1-methyl-4-piperidinylamino]pyri mido[5,4-d]pyrimidine, and 4-[(3-Chloro-4-fluorophenyl)amino]-6-[trans-4-dimethyl-aminocycohexyla mino]pyrimido[5,4-d]pyrimidine.
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申请公布号 |
US5821240(A) |
申请公布日期 |
1998.10.13 |
申请号 |
US19970811907 |
申请日期 |
1997.03.05 |
申请人 |
DR. KARL THOMAE GMBH |
发明人 |
HIMMELSBACH, FRANK;DAHMANN, GEORG;VON RUEDEN, THOMAS;METZ, THOMAS |
分类号 |
A61K31/00;A61K31/505;A61K31/519;A61K31/529;A61K31/535;A61K31/5375;A61K31/5377;A61K31/54;A61K31/541;A61K31/55;A61K31/551;A61P17/00;A61P17/06;A61P35/00;A61P37/00;A61P43/00;C07D487/04;C07D519/00;(IPC1-7):C07D487/04 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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