发明名称 |
DETECTION OF DNA DAMAGING AGENTS |
摘要 |
Recombinant DNA molecules comprising a regulatory element that activates gene expression in response to DNA damage operatively linked to a DNA sequence that encodes a light emitting reporter protein, recombinant vectors containing such DNA molecules and cells containing the DNA molecules or recombinant vectors. A method of detecting for the presence of an agent that causes or potentiates DNA damage is also disclosed which involves subjecting the above-described cells to a putative DNA damaging agent and monitoring the expression of the light emitting reporter protein from the cells. |
申请公布号 |
CA2285703(A1) |
申请公布日期 |
1998.10.08 |
申请号 |
CA19982285703 |
申请日期 |
1998.03.27 |
申请人 |
THE UNIVERSITY OF MANCHESTER INSTITUTE OF SCIENCE & TECHNOLOGY |
发明人 |
WALMSLEY, RICHARD MAURICE;HEYER, WOLF DIETRICH |
分类号 |
C12N15/09;C07K14/395;C07K14/435;C12N1/19;C12N15/12;C12N15/81;C12Q1/02;C12Q1/68;G01N33/50;(IPC1-7):C12Q1/68;C12N5/12 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|