HUMAN NEURONATIN

摘要

The present invention provides a polynucleotide which identifies and encodes a novel human neuronatin (HNEU). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding HNEU. The invention also provides for the use of substantially purified HNEU and its agonists in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of HNEU. Additionally, the invention provides for the use of antisense molecules to HNEU in pharmaceutical compositions for treatment of diseases associated with the expression of HNEU. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding HNEU or anti-HNEU antibodies which specifically bind to HNEU.