BIPHENYL DERIVATIVES AND MEDICINAL COMPOSITIONS

摘要

Biphenyl derivatives represented by general formula (1) and pharmacologically acceptable salts thereof wherein A represents a single bond, -CH2-, -CO-, -CS-or -SO2-; B represents a single bond or -CH2; R1 represents hydrogen, -OH, NR11R12 (wherein R11 and R12 independently represent each hydrogen or C1-4 alkyl), -OCOCH3 or halogen and R2 represents hydrogen, or R1 and R2 may form together =O; and R3 represents hydrogen or C1-4 alkyl. In said formula, the absolute configuration at the position a may be any of R- and Sconfigurations. These compounds are highly excellent in safety and efficacy and useful, in particular, as vasopressin receptor antagonists.