发明名称 |
Anti ganglioside monoclonal antibodies |
摘要 |
The present invention relates to immunotherapy strategies for the treatment of malignancies. The present immunotherapy strategies have gangliosides as a target. Gangliosides are glycosphingolipids which are present on normal cells and on malignant cells. On malignant cells they are more abundant and expressed in a different organization and conformation. The present invention provides antibodies which recognize these gangliosides, which antibodies are specific, have recurrent idiotypes and have value as immunoregulators. The invention further provides anti-idiotypic antibodies against anti-ganglioside antibodies. These are useful in vaccination strategies.
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申请公布号 |
US5817513(A) |
申请公布日期 |
1998.10.06 |
申请号 |
US19940353560 |
申请日期 |
1994.12.09 |
申请人 |
CENTRO DE INMUNOLOGIA MOLECULAR |
发明人 |
LOPEZ, ANA MARIA VAZGUEZ;FERNANDEZ, ANGEL MAURO ALFONSO;RODRIGUEZ, ROLANDO PEREZ;ABRAHAM, AMPARO E. MACIAS;VALCARCEL, CARLOS MANUEL ALVAREZ;RUIZ, MARIA ELIANA LANIO |
分类号 |
G01N33/53;A61K38/00;A61K39/395;A61P35/00;C07K16/00;C07K16/30;C07K19/00;C12N5/10;C12N5/20;C12N15/02;C12P21/08;G01N33/577;(IPC1-7):C12N5/12 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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