发明名称 |
Antibodies for inhibiting blood coagulation and methods of use thereof |
摘要 |
The invention includes antibodies that provide superior anti-coagulant activity by binding native human TF with high affinity and specificity. Antibodies of the invention can effectively inhibit blood coagulation in vivo. Antibodies of the invention can bind native human TF, either alone or present in a TF:VIIa complex, effectively preventing factor X binding to TF or that complex, and thereby reducing blood coagulation. Preferred antibodies of the invention specifically bind a conformational epitope predominant to native human TF, which epitope provides an unexpectedly strong antibody binding site. |
申请公布号 |
AU6455998(A) |
申请公布日期 |
1998.09.29 |
申请号 |
AU19980064559 |
申请日期 |
1998.03.10 |
申请人 |
SUNOL MOLECULAR CORPORATION |
发明人 |
HING C WONG;JIN-AN JIAO;ESPERANZA LILIANA NIEVES;LAWRENCE LUEPSCHEN |
分类号 |
C12N15/09;A61K38/00;A61K39/395;A61P7/02;A61P9/00;C07K16/28;C07K16/36;C07K16/46;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/13;C12P21/08;C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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