摘要 |
Stabilized medicinal aerosol solution formulations comprising medicaments that degrade or decompose by interaction with solvents or water, an HFC propellant, a cosolvent and an acid are described. Further, specific medicinal aerosol solution formulations comprising ipratropium bromide or fenoterol, ethyl alcohol, 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoropropane, and either an inorganic acid or an organic acid are described. The acids are present in amounts sufficient to reduce the degradation of the medicaments to acceptable levels. |
申请人 |
BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. |
发明人 |
JAGER, PAUL, D.;KONTNY, MARK, J.;NAGEL, JURGEN, H. |