发明名称 |
ANTIANGIOGENIC DRUG TO TREAT CANCER, ARTHRITIS AND RETINOPATHY |
摘要 |
<p>Peptides having the formula: T-Gly-Val-D-Ile-Thr-Arg-Ile-U, V-Gly-D-Val-Ile-D-Thr-D-Arg-D-Ile-W, X-D-Arg-D-Ile-D-Arg-D-Thr-Ile-D-Val-Y, and Z-Gly-Val-Ile-Thr-Arg-Ile-U wherein T is absent or is selected from N-protecting group and a polypeptide of up to 12 amino acid residues optionally terminated with an N-protecting group; U is selected from Arg and Arg-NR<1>R<2> wherein R<1> and R<2> are independently selected from hydrogen and alkyl of one to four carbon atoms; V is absent or an N-protecting group; W is selected from D-Arg and D-Arg-NR<1>R<2>; X is absent or an N-protecting grou; Y is selected from Gly and Gly-NR<1>R<2>; and Z is 1-12 amino acid residues optionally terminated with an N-protecting group wherein at least one of the amino acid residues is a D-amino acid residue inhibit angiogenesis and are useful in the treatment of disease states such as cancer, arthritis, macular degeneration and diabetic retinopathy in which angiogenesis plays a role.</p> |
申请公布号 |
WO9841542(A1) |
申请公布日期 |
1998.09.24 |
申请号 |
WO1998US05327 |
申请日期 |
1998.03.16 |
申请人 |
ABBOTT LABORATORIES;NORTHWESTERN UNIVERSITY |
发明人 |
HENKIN, JACK;BOUCK, NOEL, P.;DAWSON, DAVID, W.;SCHNEIDER, ANDREW, J. |
分类号 |
A61K38/00;A61P17/06;A61P27/02;A61P29/00;A61P35/00;C07K7/06;C07K7/08;C07K14/47;C07K14/78;(IPC1-7):C07K14/78;A61K38/39 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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