| 摘要 |
A multiply-displayed peptide structure is provided for the serodiagnosis of HSV-2 antibodies, preferably by ELISA. The structure has the formula (1)): [(X<SP>1</SP>) p -16aa sequence (X<SP>2</SP>) q -Sp] n -core, wherein "16aa sequence" represents a sequence (SEQ ID NO: 68) X<SP>1</SP> and X<SP>2</SP> which may be the same or different represent from 1 to 6 non-interfering amino acid residues, which may be the same or different; Sp represents a spacer group extending outwardly from the core; n is at least 4; p is 0 or 1; q is 0 or 1; and the linkage between the core and the spacer group may be chemical or physical. Preferably p is 1, q is 1, X<SP>1</SP> is Pro, n is 4, and the core is a branched lysine core, whereby the whole structure is a peptide. The monomeric peptides (X<SP>1</SP>) p -16aa sequence -(X<SP>2</SP>) q -(Sp) r , where r is 0 or 1 and their functional derivatives are useful intermediates in preparing the above structures.
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