Sialyl Lex analogues as inhibitors of cellular adhesion

摘要

The present invention relates to analogues of sialyl Lex the inhibit cellular adhesion between a selectin and cell that express sialyl Lex on their surfaces, as well as methods and compositions using the same, intermediates and methods for the preparation of the celluar adhesion inhibitor compounds and their intermediates. A contemplated intermediate or inhibitor compound has a structure that corresponds to that of Formula A, <IMAGE> A +TR <IMAGE> wherein: Z is selected from the group consisting of hydrogen, C1-C6 acyl and <IMAGE>