| 摘要 |
Mixtures of peptoids are provided. The subject peptoid mixtures comprise at least five non-homopolymeric polymers of differing sequences having a selected number of monomer units. The polymers of the subject mixtures are preferably selected from the group of compounds of the general formula: Xa-(NR-CH2-CO)n-Xb, Xa-(O-CHR-CO)n-Xb, Xa-(NH-CHR-CS)n-Xb, Xa-(NOH-CHR-CO)n-Xb, Xa-(O-CHR-CH2-CO)n-Xb, Xa-(NH-CHR-CH2-SO2)n-Xb, Xa-(NR-CH2CH2-SO2)n-Xb, Xa-(NR-CH2CH2-NHCO)n-Xb and Xa-(NR-CH2CH2-OCO)nXb, where each R is independently a side chain capable of interaction with a protein, carbohydrate, lipid or nucleic acid; n is an integer from 2 to 50, inclusive; and Xa and Xb are each independently H, lower alkyl, lower aryl, aralkyl, lower acyl, a polypeptide of 1-100 amino acids, or an effector molecule capable of exhibiting biological activity.
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