发明名称 |
Vaccines containing bacteria attenuated by mutations in two genes of the aromatic amino acid biosynthetic pathway |
摘要 |
An attenuated microorganism harboring two mutated genes, each of which is located in the organisms aromatic pathway is provided. These organisms can usefully form the basis of a vaccine. They can be genetically engineered so as to express antigens from other pathogens and thus form the basis of a range of multi-valent vaccines.
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申请公布号 |
US5811105(A) |
申请公布日期 |
1998.09.22 |
申请号 |
US19950449297 |
申请日期 |
1995.05.24 |
申请人 |
GLAXO WELLCOME, INC. |
发明人 |
DOUGAN, GORDON;CHATFIELD, STEVEN NEVILLE;HORMAECHE, CARLOS ESTENIO |
分类号 |
A61K39/02;A61K39/112;(IPC1-7):A61K39/02;C12N15/00;C12N1/00 |
主分类号 |
A61K39/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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