发明名称 |
(men1), the gene associated with multiple endocrine neoplasia type 1, menin polypeptides, and uses thereof |
摘要 |
This invention relates to the discovery of a novel tumor suppressor gene which is associated with multiple endocrine neoplasia type 1. The gene has been designated MEN1 and the gene product is menin. The absence of this protein and associated mutations in the corresponding gene have been identified in individuals suffering from multiple endocrine neoplasia type 1. The identification of this marker for multiple endocrine neoplasia type 1 has diagnostic uses as well as for gene therapy. |
申请公布号 |
AU6541998(A) |
申请公布日期 |
1998.09.22 |
申请号 |
AU19980065419 |
申请日期 |
1998.03.04 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED B |
发明人 |
SETTARA C. CHANDRASEKHARAPPA;SIRADANAHALLI C. GURU;PACHIAPPAN MANICKAM;FRANCIS S. COLLINS;MICHAEL R. EMMERT-BUCK;LARISA V. DEBELENKO;IRINA A LUBENSKY;LANCE A. LIOTTA;SUNITA K. AGARWAL;ALLEN M. SPIEGEL;A. LEE BURNS;STEPHEN J. MARX |
分类号 |
A01K67/027;A61K48/00;C07K14/47;C07K16/18;C12N5/10;C12N15/09;C12N15/12;C12Q1/68;G01N33/53 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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