| 摘要 |
An imide derivative represented by general formula (1) [wherein Z is represented by formula (2) (wherein B represents a carbonyl group or the like; for R<1>, R<2>, and R<3>, R<1> and R<2> combine with each other to form an optionally substituted hydrocarbon ring with R<3> representing a hydrogen atom, or alternatively R<1> and R<3> may combine with each other to form an optionally substituted hydrocarbon ring with R<2> representing a hydrogen atom; and n is 0 or 1), or a group represented by R<4>CO-NR<5>-(wherein R<4> represents an optionally substituted phenyl group or the like; and R<5> represents a hydrogen atom or a lower alkyl group); W represents an optionally substituted lower alkylene group or the like, G represents a nitrogen atom or a methine group; Ar represents an optionally substituted pyrimidyl group or the like; and Y represents a hydrogen atom or -(CH2)m- (wherein m is 1, 2 or 3) with the other end being optionally bonded to the o-position of Ar] or a pharmaceutically acceptable salt thereof is an antagonist against a dopamine D4 receptor that does not cause an extrapyramidal syndrom associated with dopamine D2 receptor antagonism and is useful as a therapeutic agent for metal disorder, e.g., schizophrenia in a negative state or the like and L-DOPA mental disorder during treatment of Parkinson's disease. |
