Compounds and methods are described for producing streptavidin mutants with changed affinities. In particular, modifications to the sequence of the natural streptavidin gene is described to create amino acid substitutions resulting in greater affinity for biotin subsitutes than for biotin.
申请公布号
CA2283716(A1)
申请公布日期
1998.09.17
申请号
CA19982283716
申请日期
1998.03.13
申请人
TRUSTEES OF BOSTON UNIVERSITY
发明人
SMITH, CASSANDRA;SANO, TAKESHI;REZNIK, GABRIEL O.;VAJDA, SANDOR;CANTOR, CHARLES R.