L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides

摘要

PCT No. PCT/US95/01253 Sec. 371 Date Jan. 24, 1997 Sec. 102(e) Date Jan. 24, 1997 PCT Filed Jan. 30, 1995 PCT Pub. No. WO95/20595 PCT Pub. Date Aug. 3, 1995A method for stabilizing an oligonucleotide by including a beta -L-2'-deoxy-2'-fluoro-arabinofuranosyl nucleoside at the 5'-terminus, the 3'-terminus, or in the interior of the oligonucleotide. The oligonucleotide can be used in the modulation of gene expression through a process wherein a synthetic oligonucleotide is hybridized to a complementary nucleic acid sequence to inhibit transcription or replication of DNA or to inhibit translation or processing of RNA.