发明名称 |
Intercalators having affinity for DNA and methods of use |
摘要 |
Intercalator compounds are provided which are comprised of intercalator moieties, or substituted intercalator moieties, having one or more functionalized chains, or moieties, and which compounds provide a high affinity for binding to the DNA molecule and show reduced self-quenching, while providing superior transport kinetics. The compounds have been found to provide enhanced fluorescence when bound to a DNA molecule within a fluorescent flow cytometry environment which is about eight to ten times brighter in fluorescence than "bis" structure conventional intercalating agents and other known intercalating agents utilized in flow cytometry environment.
|
申请公布号 |
US5808077(A) |
申请公布日期 |
1998.09.15 |
申请号 |
US19950463324 |
申请日期 |
1995.06.05 |
申请人 |
ABBOTT LABORATORIES |
发明人 |
BIENIARZ, CHRISTOPHER;HUFF, JEFFREY BRUCE;HENRARD, DENIS R. |
分类号 |
C07D219/14;C07D221/12;C07D413/06;C07D417/06;(IPC1-7):C07D215/00 |
主分类号 |
C07D219/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|