| 发明名称 |
Quinuclidine derivatives |
| 摘要 |
PCT No. PCT/US92/03317 Sec. 371 Date May 23, 1994 Sec. 102(e) Date May 23, 1994 PCT Filed Apr. 28, 1992 PCT Pub. No. WO92/21677 PCT Pub. Date Dec. 10, 1992Compounds of the formula <IMAGE> I wherein R1 is methoxy and R2 is selected from the group consisting of methyl, ethyl, isopropyl, sec-butyl and tert-butyl; and the pharmaceutically acceptable salts of such compounds. These compounds are substance P antagonists and useful in the treatment of gastrointestinal disorders, inflammatory disorders, central nervous system disorders and pain.
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| 申请公布号 |
US5807867(A) |
申请公布日期 |
1998.09.15 |
| 申请号 |
US19940211120 |
申请日期 |
1994.05.23 |
| 申请人 |
PFIZER INC. |
发明人 |
ITO, FUMITAKA;KONDO, HIROSHI;NAKANE, MASAMI;SHIMADA, KAORU;LOWE, III, JOHN ADAMS;ROSEN, TERRY JAY |
| 分类号 |
C07D453/02;A01N43/90;A61K;A61K31/395;A61K31/435;A61K31/439;A61K31/44;A61K31/445;A61P1/00;A61P1/16;A61P11/00;A61P25/00;A61P25/04;A61P25/20;A61P25/24;A61P29/00;A61P43/00;C07D;C07D453/00;C07D453/04;C07D471/10;(IPC1-7):A01N43/90 |
主分类号 |
C07D453/02 |
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