4,4-DIFLUORO-2,3,4,5-TETRAHYDRO-1H-1-BENZAZEPINE DERIVATIVES AND DRUG COMPOSITIONS CONTAINING THEM

摘要

4,4-Difluoro-2,3,4,5-tetrahydro-1H-1-benzazepine derivatives represented by formula (1) or salts thereof (wherein A is 5-membered heteroarylene; B is optionally substituted aryl or 5- or 6-membered heteroaryl; D is carbonyl or lower alkylene; R1 is -NR3R4, -O-(lower alkyl) or OH; R2 is optionally halogenated lower alkyl, -O-(lower alkyl), -S-(lower alkyl) or -CO-(lower alkyl); R3 and R4 are each independently hydrogen, lower alkyl or the like; and n is 0, 1 or 2). The above compounds exhibit the oxytocin antagonism and are effective in inhibiting threatened premature birth or abortion, or precesarean birth and useful as remedies for dysmenorrhea and so on.