NOVEL BICYCLONUCLEOSIDE AND OLIGONUCLEOTIDE ANALOGUE

摘要

Oligo- or polynucleotide analogues each having one or two structures represented by general formula (I) wherein B represents pyrimidine or purine nucleic acid base or analogue thereof. They can provide antisense molecules of oligonucleotide analogues that are less likely to undergo enzymatic hydrolysis in vivo, have a high capability of binding to sense chains, and can be easily synthesized.