发明名称 SUBSTITUTED 2,4-DIAMINOPYRIMIDINES
摘要 The invention is concerned with compounds of general formula (I), wherein R1 signifies lower-alkoxy, R2 signifies hydroxy or lower-alkoxy, R3 signifies hydrogen, cyano, alkyl, alkenyl, cycloalkyl, aryl, heterocycyl, aralkyl, arylQ-alkyl, heterocyclalkyl or a group of the formula -(CH2)n-, Q signifies -SO-; R4, R4' each independently signify hydrogen, alkyl, aryl or heterocyclalkyl, R5 signifies hydrogen, alkyl, alkoxy, aryl or heterocycyl, or R4 and R5 together can form a group -(CH2)n-, and n is a whole number of 2 to 5, as well as pharmaceutically usable salts thereof; the use of these compounds and their salts as therapeutically active substances; medicaments based on these substances and their production; the use of these substances as medicaments and for the production of antibacterially-active medicaments; as well as the manufacture of the compounds of formula (I) and their pharmaceutically acceptable salts and intermediates for their manufacture.
申请公布号 CA2281642(A1) 申请公布日期 1998.09.11
申请号 CA19982281642 申请日期 1998.02.24
申请人 F. HOFFMANN-LA ROCHE AG 发明人 WYSS, PIERRE-CHARLES;GUERRY, PHILIPPE;SPECKLIN, JEAN-LUC;HUBSCHWERLEN, CHRISTIAN;JOLIDON, SYNESE
分类号 A61K31/505;A61K31/506;A61K31/5377;A61P31/04;C07D401/14;C07D403/10;C07D403/14;C07D405/14;C07D409/14 主分类号 A61K31/505
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