| 摘要 |
<p>The present invention is directed to a ketonitrile derivative represented by the following formula (1): <CHEM> (wherein R<1> is a hydrogen atom or a lower alkyl group; each of R<2>, R<3>, R<4>, and R<5>, which may be identical to or different from each other, is a hydrogen atom, a halogen atom, a nitro group, a lower alkyl group, a lower alkoxyl group, or a substituted or unsubstituted phenoxy group; X is a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted heterocyclic group; Y is a substituted or unsubstituted aromatic hydrocarbon group, a substituted or unsubstituted heterocyclic group, a carbonyl group that has been substituted by a substituted or unsubstituted aromatic hydrocarbon group, a carbonyl group that has been substituted by a substituted or unsubstituted heterocyclic group, an N,N-di-substituted carbamoyl group, or an alkyl group that has been substituted by a heterocyclic group) or a salt thereof, and to an antibacterial agent as well as to a drug containing, as the effective ingredient, the ketonitrile derivative or the salt. This compound exhibits excellent antibacterial activity against gram-positive bacteria and gram-negative bacteria.</p> |
