发明名称 |
Process for preparing solid pharmaceutical dosage forms |
摘要 |
This invention relates to a process for the preparation of an oral solid rapidly disintegrating dosage form of a pharmaceutically active substance which has an unacceptable taste which process comprises: (i) forming a solution or a suspension in a solvent of a water soluble or water dispersible carrier, a filler and the pharmaceutically active substance with the unacceptable taste in association with a lipid, the weight ratio of the pharmaceutically active substance to the lipid being in the range of from 1:1 to 1:10 and the weight ratio of the carrier to the lipid being in the range of from 5:1 to 1:15; (ii) forming discrete units of the suspension or solution; and (iii) removing the solvent from the discrete units under conditions whereby unit dosages are formed comprising a network of carrier/filler carrying a dosage of the pharmaceutically active substance in association with the lipid; oral solid rapidly disintegrating dosage forms prepared by such a process are also provided. |
申请公布号 |
AU6221298(A) |
申请公布日期 |
1998.09.08 |
申请号 |
AU19980062212 |
申请日期 |
1998.02.12 |
申请人 |
R.P. SCHERER CORPORATION |
发明人 |
LEON GROTHER;MICHAEL HALL;DOUGLAS BRYANS;RICHARD GREEN;PATRICK KEARNEY |
分类号 |
A61K9/00;A61K9/20;A61K31/192;A61K31/485;A61K47/44 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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