| 摘要 |
Pharmaceutical compositions for use in the field of therapeutic chemistry and particularly that of pharmaceutical technology are disclosed. The compositions are suitable for rectal delivery and consist of an effervescent mixture of an alkali metal bicarbonate and a predetermined acid reaction compound selected from the group which consists of monosodium or monopotassium phosphate, monosodium citrate, pyroglutamic acid and glutamic acid, combined or mixed with one or more diluents or carriers suitable for preparing a pharmaceutical form for rectal delivery. A method for making pharmaceutical compositions for rectal delivery, wherein an acid reaction salt selected from monosodium phosphate, monopotassium phosphate, monosodium citrate, pyroglutamic acid and glutamic acid, and an alkali metal bicarbonate are incorporated into a hydrophilic excipient then an opacifier, and the mixture is added to a fatty excipient that melts at a temperature adjacent to the body temperature, is also disclosed. Said compositions may be used as a laxative drug. |
