Method for preparing aromatic compounds

摘要

PROBLEM TO BE SOLVED: To carry out control of halogenation and selectively obtain a halogenated aromatic compound by using a directional group. SOLUTION: A reaction mixture solution containing (A) at least one aryl or heteroaryl compound having Z-directional group [CO2 R<1> , CONR<2> R<3> , COR<4> or cyano (R<1> to R<3> are each H or a 1-6C alkyl; R<4> is H or a substituted 1-6C alkyl)] and one or two halo groups, (B) a copper-containing a dehalogenating agent [e.g. copper (I) oxide] in an amount of about 0.01-5.0mol equivalent based on a halogen group removed and (C) an acid (e.g. 1-10C carboxylic acid) in an amount of at least 1.0mol equivalent based on the halo group removed is heated at 95-220 deg.C to provide the objective aryl or heteroaryl compound capable of selectively removing a halogen atom from a halogenated aryl or a heteroaryl compound.