发明名称 ISOLATION AND STRUCTURAL ELUCIDATION OF THE CYTOSTATIC LINEAR AND CYCLO-DEPSIPEPTIDES DOLASTATIN 16, DOLASTATIN 17, AND DOLASTATIN 18
摘要 Cytostatic linear and cyclo-depsipeptides, "Dolastatin 16", "Dolastatin 18", and "Dolastatin 17", are disclosed which are obtained from Indian Ocean shellless mollusk Dolabella auricularia. Methods of using the substances to inhibit malignant cell growth associated with neoplastic diseases in animals and humans are also disclosed, as well as pharmaceutical preparations containing Dolastatin 16, Dolastatin 17, and Dolastatin 18.
申请公布号 CA2282504(A1) 申请公布日期 1998.08.27
申请号 CA19982282504 申请日期 1998.02.23
申请人 ARIZONA BOARD OF REGENTS 发明人 XU, JUN-PING;PETTIT, G.R.
分类号 A61K38/00;A61P35/00;C07K5/06;C07K11/00;C07K14/435;(IPC1-7):A61K38/12;C07K5/00;C07K7/00;C07K16/00;C07K17/00 主分类号 A61K38/00
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