| 发明名称 |
ANTIBODY FRAGMENT-POLYMER CONJUGATES AND HUMANIZED ANTI-IL-8 MONOCLONAL ANTIBODIES |
| 摘要 |
<p>Humanized anti-IL-8 monoclonal antibodies and variants thereof are described for use in diagnostic applications and in the treatment of inflammatory disorders. Also described is a conjugate formed by an antibody fragment covalently attached to a non-proteinaceous polymer, wherein the apparent size of the conjugate is at least about 500 kD. The conjugate exhibits substantially improved half-life, mean residence time, and/or clearance rate in circulation as compared to the underivatized parental antibody fragment.</p> |
| 申请公布号 |
CA2281794(A1) |
申请公布日期 |
1998.08.27 |
| 申请号 |
CA19982281794 |
申请日期 |
1998.02.20 |
| 申请人 |
GENENTECH, INC. |
发明人 |
SHAHROKH, ZAHRA;ZAPATA, GERARDO A.;LEONG, STEVEN R.;KOUMENIS, IPHIGENIA;PRESTA, LEONARD G.;HSEI, VANESSA |
| 分类号 |
C12N15/09;A61K38/00;A61K47/48;A61P37/00;C07K16/24;C07K16/46;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/13;(IPC1-7):C12N15/13;C12N15/85 |
主分类号 |
C12N15/09 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
