Methods for preserving platelets at temperatures of less than about 15 DEG C. with retention of hemostatic activity are provided. The method uses a first agent for inhibiting actin filament severing and a second agent for inhibiting actin polymerization. Contacting the platelets with the first and second agents prior to exposure to cold temperature prevents cold-induced platelet activation.
申请公布号
EP0684762(B1)
申请公布日期
1998.08.19
申请号
EP19940909649
申请日期
1994.02.17
申请人
BRIGHAM AND WOMEN'S HOSPITAL, INC.
发明人
STOSSEL, THOMAS, P.;HARTWIG, JOHN, H.;JANMEY, PAUL, A.