2-PHENYL-2-(2'-PIPERIDINYLIDENE)ACETATE DERIVATIVE, PROCESS FOR MANUFACTURING THE SAME, AND PROCESS FOR MANUFACTURING OPTICALLY ACTIVE 2-PHENYL-2-(2'-PIPERIDINYL)ACETATE DERIVATIVE BY ASYMMETRICALLY HYDROGENATINGTHE SAME

摘要

Disclosed is a 2-phenyl-2-(2'-piperidinylidene)acetate derivative suitably used for a raw material of a 2-phenyl-2-(2'-piperidinyl)acetate derivative and a process for manufacturing the same. Also disclosed is a process for manufacturing an optically active 2-phenyl-2-(2'- piperidinyl)acetate derivative which is a major intermediate for an antidepressant. The 2-phenyl-2-(2'- piperidinylidene)acetate derivative is manufactured by cyclizing a 7-(N-substituted amino)-3-oxo-2-heptanoate derivative. The optically active 2-phenyl-2-(2'- piperidinyl)acetate derivative is manufactured by asymmetrically hydrogenating the 2-phenyl-2-(2'- piperidinylidene)acetate derivative in the presence of a complex of a Group VIII transition metal or an acid.