METHODS AND COMPOSITIONS FOR DELIVERY OF THERAPEUTIC AGENTS TO BONE TISSUE EMPLOYING CONJUGATES OF NEGATIVELY CHARGED PEPTIDE OLIGOMERS WITH THERAPEUTIC AGENTS

摘要

The invention provides conjugates of negatively charged peptide oligomers with therapeutic agents, moieties capable of recruiting endogenous bone-affecting agents, or imaging agents, useful for delivering the agents to bone tissue or calcified masses, and the methods of use thereof. The negatively charged peptide oligomers bind strongly but reversibly to bone tissue and calcified masses with a controllable affinity and retention time on the tissue or mass.