| 摘要 |
N-[(Substituted five-membered heteroaryl)carbonyl]guanidine derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, wherein (a) represents (b) or (c) (wherein X<1> represents oxygen, sulfur, or NR<3>; and X<2> represents nitrogen or CR<4>); R<1> represents optionally substituted aryl or optionally substituted five- or six-membered monocyclic heteroaryl; R<2> represents hydrogen, halogeno, optionally halogen-substituted lower alkyl, lower alkoxy, lower alkylthio, or optionally protected amino, provided that when (d) is (e), R<2> is neither hydrogen nor ethoxy; and R<3> and R<4> each represents hydrogen or optionally halogen-substituted lower alkyl. They are useful as a drug, especially an Na<+>/H<+> exchanger inhibitor, for the prevention, treatment, or diagnosis of various diseases in which an Na<+>/H<+> exchanger participates, such as hypertension, arrhythmia, angina pectoris, myocardial infarct, arteriosclerosis, and complications of diabetes. |
