NOVEL SOLID-PHASE SYNTHESIS TECHNIQUES FOR PREPARING MULTIPLE ANALOGOUS COMPOUNDS

摘要

This application relates to a process for synthesizing multiple analogous compounds, which process comprises: (a) reacting a solid-phase supported intermediate with a cleaving/condensing reagent by a means which results in the formation of a solution-phase condensation product and affords remainder solid-phase supported intermediate; (b) separating the solution-phase condensation product formed by step (a) from the solid-phase; (c) reacting remainder solid-phase supported intermediate with a cleaving/condensing reagent distinct from the cleaving/condensing reagent applied in step (a) to give a solution-phase condensation product analogous to the solution-phase condensation product formed by step (a); (d) separating the solution-phase condensation product formed by step (c) from the solid-phase; and (e) optionally repeating process steps (c) and (d) one or more additional times, if remainder solid-phase supported intermediate is present, using a further distinct cleaving/condensing reagent for each repetition to give additional analogous solution-phase.