发明名称 |
VASCULAR ENDOTHELIAL GROWTH FACTOR C (VEGF-C) PROTEIN AND GENE, MUTANTS THEREOF, AND USES THEREOF |
摘要 |
Provided are purified and isolated VEGF-C polypeptides capable of binding to at least one of KDR receptor tyrosine kinase (VEGFR-2) and Flt4 receptor tyrosine kinase (VEGFR-3); analogs of such peptides that have VEGF-C-like or VEGF-like biological activities or that are VEGF or VEGF-C inhibitors; polynucleotides encoding the polypeptides; vectors and host cells that embody the polynucleotides; pharmaceutical compositions and diagnostic reagents comprising the polypeptides; and methods of making and using the polypeptides.
|
申请公布号 |
CA2279554(A1) |
申请公布日期 |
1998.08.06 |
申请号 |
CA19982279554 |
申请日期 |
1998.02.02 |
申请人 |
THE LUDWIG INSTITUTE FOR CANCER RESEARCH;HELSINKI UNIVERSITY LICENSING LTD. OY |
发明人 |
JOUKOV, VLADIMIR;ALITALO, KARI |
分类号 |
A01K67/027;A61K38/00;A61K38/22;A61K39/395;A61K48/00;A61P9/00;A61P17/02;A61P43/00;C07K14/475;C07K14/52;C07K16/22;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/18;C12P21/02;C12Q1/68;C12R1/91;(IPC1-7):C12N15/12;C12N15/10;C07K16/24;G01N33/50;C12N15/62 |
主分类号 |
A01K67/027 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|