| 摘要 |
<p>A plurality of oligonucleotides are synthesized at a plurality of locations on a substrate (10) using a plurality of dispensing bars (12). Each of the plurality of dispensing bars (12) has a respective plurality of dispensing heads arranged along a respective axis. Each of the plurality of dispensing bars (12) is operative to selectively deposit a volume of a respective one of a plurality of nucleotide bases in any of a row of locations. A positioning mechanism (52) positions the substrate (10) with respect to the plurality of dispensing bars (12). A controller (56) controls the plurality of dispensing bars (12) and the positioning mechanism (52) so that, at each of the plurality of locations, a respective sequence of nucleotide bases is deposited to form a respective oligonucleotide.</p> |
