Protein rab3 GEP

摘要

The present invention provides a protein Rab3 GEP which is a GDP/GTP exchange protein active on the Rab3 subfamily small G proteins, which has an amino acid sequence of Sequence ID No. 1 or an amino acid sequence substantially the same as that of the Sequence ID No. 1, a cDNA sequence coding this protein, and genomic DNA sequence to which the cDNA sequence or a part thereof hybridizes. According to the invention, there is provided a novel protein (Rab3 GEP) specific for the Rab3 subfamily small G proteins which are involved in intercellular vesicle trafficking, and a genetic material for industrial utilization thereof. This protein is useful, not only for clarification of the molecular mechanism of intracellular vesicle trafficking which is an important cellular event, but also for development of diagnosis, prevention and therapy of neural diseases and the like.