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发明名称 Nitric oxide releasing compounds as protective agents in ischemia reperfusion injury
摘要 The present invention provides a method for treating oxygen free radical induced tissue damage associated with ischemia reperfusion injury, wherein nitric oxide is delivered to target cells/tissues through the administration of a nitric oxide-containing compound that spontaneously releases nitric oxide under physiological conditions without requiring the presence of oxygen.
申请公布号 US5789447(A) 申请公布日期 1998.08.04
申请号 US19950527314 申请日期 1995.09.12
申请人 THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES;THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE 发明人 WINK, JR., DAVID A.;MITCHELL, JAMES B.;RUSSO, ANGELO;KRISHNA, MURALI C.;HANBAUER, INGEBORG;GRISHAM, MATTHEW B.;GRANGER, DANIEL NEIL
分类号 C07D295/22;A61K31/10;A61K31/13;A61K31/135;A61K31/14;A61K31/15;A61K31/16;A61K31/195;A61K31/198;A61K31/215;A61K31/44;A61K31/4402;A61K31/4406;A61K31/4409;A61K31/4418;A61K31/445;A61K31/4468;A61K31/495;A61K31/496;A61K38/00;A61K45/00;A61P1/00;A61P1/04;A61P3/08;A61P7/00;A61P9/00;A61P9/08;A61P9/10;A61P9/12;A61P11/00;A61P25/28;A61P29/00;A61P35/00;A61P37/06;A61P43/00;C07D211/98;C07D213/42;C07D271/06;(IPC1-7):A61K31/40 主分类号 C07D295/22
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