| 摘要 |
PROBLEM TO BE SOLVED: To obtain a protein, capable of regulating a signal transmission route such as a morphological change in a cell, formation or metastasis of tumor or constriction of vascular smooth muscles, derived from a human and useful for diagnosing malignant tumor, etc., by providing the protein with an active type Rho protein-binding ability, etc. SOLUTION: This protein has characteristics of (i) having an active type Rho protein-binding ability, (ii) having protein kinase activities, (iii) capable of accelerating the protein kinase activities by binding to the active type Rho protein and (iv) having a gene located at a human chromosome 2p24. The protein (derivative) contains (v) an amino acid sequence represented by the formula or (vi) the amino acid sequence represented by the formula in which one or more amino acid sequences are added and/or inserted and/or one or more amino acid sequences are substituted and/or deleted, has the active type Rho protein- binding ability, contains an amino acid sequence having protein kinase activities and is obtained by culturing a host cell containing a nucleic acid capable of coding the protein (derivative). |
