Increased production of secreted proteins by recombinant eukaryotic cells

摘要

PCT No. PCT/FI93/00402 Sec. 371 Date Jan. 16, 1996 Sec. 102(e) Date Jan. 16, 1996 PCT Filed Oct. 6, 1993 PCT Pub. No. WO94/08024 PCT Pub. Date Apr. 14, 1994The invention relates to recombinant DNA technology. Specifically this invention relates to new recombinant eukaryotic cells transformed with SSO genes. Eukaryotic cells transformed with several copies of SSO genes, or overexpressing the Sso protein by some other means, have an increased capacity to produce secreted foreign or endogenous proteins. Further, the said new recombinant cells, when transformed with genes expressing suitable hydrolytic enzymes can utilize appropriate macromolecular compounds more efficiently, which results in increased cell mass production and/or more versatile utilization of the compounds in relevant biotechnical applications.