4,6-diarylpyrimidine derivatives and salts thereof

摘要

PCT No. PCT/JP96/01022 Sec. 371 Date Nov. 27, 1996 Sec. 102(e) Date Nov. 27, 1996 PCT Filed Apr. 12, 1996 PCT Pub. No. WO96/32384 PCT Pub. Date Oct. 17, 1996Described are a 4,6-diarylpyrimidine derivative represented by the following formula (1): <IMAGE> (1) wherein R represents a heterocyclic ring which may be substituted by one to four lower alkyl groups or an amino group and Ar represents a phenyl, naphthyl or aromatic heterocyclic group which may have one to four substituents, and a salt thereof; a preparation process therefor; and a pharmaceutical containing it as an effective ingredient. It has excellent neovascular inhibitory action and is useful as a therapeutic agent for solid cancer, rheumatism, diabetic retinopathy or psoriasis.