CRYSTAL OF 2-2(2-PYRIDYLMETHYLSULFINYL) BENZIMIDAZOLE COMPOUND AND ITS PRODUCTION

摘要

PROBLEM TO BE SOLVED: To obtain the crystal of the subject compound essentially free from solvent and useful as a pharmaceutical agent such as an antitumor agent by recrystallizing the subject compound in a hydrated alcohol and suspending and stirring the obtained water-ethanol solvated crystal of the subject compound in hot water. SOLUTION: A compound of the formula [ring A may have substitutes; R<1> is H or an N-protecting group; R<2> , R<3> and R<4> are each H, a (halogen- substituted)alkyl, etc.], especially 2-[[3-methyl-4-(2,2,2,-trifluoroethoxy)pyridin-2- yl]methylsulfinyl]benzimidazole is recrystallized from a hydrated alcohol composed of 1pt.vol. of water and 2-30pts.vol. of an alcohol, 1pt. of the obtained solvated compound crystal is suspended in about 2-20pts. of water and stirred for 0.05-5hr while keeping the water temperature between room temperature and 90 deg.C and the obtained desolvated crystal is dried under reduced pressure or in vacuum at about 20-60 deg.C for 5-48hr to obtain the crystal of the objective compound.