发明名称 |
Cationic phospholipids for transfection |
摘要 |
A novel class of cationic phospholipids and novel method for their synthesis are disclosed. The class of phospholipids comprises phosphotriester derivatives of phosphoglycerides and sphingolipids. It has been unexpectedly found that liposomes comprising one or more of these cationic phospholipids are effective in the lipofection of nucleic acids. These novel phospholipids are particularly attractive because of they are not only effective in lipofection, but are extremely cheap and easy to make.
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申请公布号 |
US5780053(A) |
申请公布日期 |
1998.07.14 |
申请号 |
US19950466417 |
申请日期 |
1995.06.06 |
申请人 |
NORTHWESTERN UNIVERSITY |
发明人 |
ASHLEY, GARY W.;MACDONALD, ROBERT C.;SHIDA, MIHO |
分类号 |
C12P9/00;A61K9/127;C07F9/09;C07F9/10;C07F9/113;C07F9/653;C12N15/88;(IPC1-7):A61K9/127 |
主分类号 |
C12P9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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