发明名称 |
Use of interleukin-10 in adoptive immunotherapy of cancer |
摘要 |
A method is provided for using interleukin-10 in adoptive immunotherapy of cancer. A population of tumor-infiltrating lymphocytes (TILs) are expanded in culture in the presence of interleukin-2 (IL-2) and interleukin-10 (IL-10). After administration of the TILs to a patient, effective amounts of both IL-2 and IL-10 are administered to enhance the tumor cell cytoxicity of the TILs and to reduce side effects caused by IL-2-induced cytokine production in the TILs and other cells of the patient.
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申请公布号 |
US5776451(A) |
申请公布日期 |
1998.07.07 |
申请号 |
US19940270805 |
申请日期 |
1994.07.05 |
申请人 |
SCHERING CORPORATION |
发明人 |
HSU, DI-HWEI;MOORE, KEVIN W.;SPITS, HERGEN |
分类号 |
A61K38/00;A61K35/14;A61K38/20;A61P35/00;C07K14/05;C07K14/54;C12N5/0783;(IPC1-7):A61K45/05 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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