Neuraminic acid derivatives, their preparation and their medical use

摘要

Compounds of formula (I): Äin which R<1> is alkyl or haloalkyl; R<2> and R<3> each represents hydrogen or aliphatic acyl; X is hydroxy, halogen, alkoxy, or a group of formula RO-, where R is aliphatic acyl; Y is a group of formula RRN- or RRN-O-, where R and R each is hydrogen or alkyl; and Z is oxygen or sulphurÜ have excellent sialidase inhibitory activity and are therefore useful for the treatment and prevention of influenza and other viral diseases where the replication of the virus is susceptible to sialidase inhibitors.