摘要 |
N-Phenyl-2-cyano-3-hydroxycrotonamide derivatives and their use as pharmaceuticals having an immunomodulatory property. The use of N-phenyl-2-cyano-3-hydroxycrotonamide derivatives of the formula I C1-C4)-alkyl, R2 is CN, CX3, WCX3, W(CH2)nCX3, NO2, (CH2)nCX3, or halogen, in which X is halogen, W is an oxygen or sulfur atom and n is an integer from 1 to 3, R3 is (C1-C4)-alkyl, (C3-C6)-cycloalkyl, CN or -CO-R4, in which R4 is (C1-C4)-alkyl or (C3-C6)-cycloalkyl, and/or their physiologically tolerable salts, for the treatment of rheumatic diseases, autoimmune diseases, and of rejection reactions of the organ recipient to the transplanted organ, is described.
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