摘要 |
PROBLEM TO BE SOLVED: To obtain powdery crystals of a monomethanesulfonic acid salt of 1-(4-amino-6,7-dimethoxy-2-quinazoliny)-4-[(2,3-dihydro-1,4-benzoxin-2 -yl) carbonyl]piperazine, called as doxazosin mesylate and provide a method for its production. SOLUTION: The powdery crystals of a monomethanesulfonic acid salt of 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodiox in-2-yl) carbonyl]piperazine have the following values of the diffraction angle 2θin an X ray diffraction analysis of powder: 7.67 deg.±0.2 deg., 8.30 deg.±0.2 deg., 9.76 deg.±0.2 deg., 10.91 deg.±0.2 deg., 11.61 deg.±0.2 deg., 14.7 deg.±0.2 deg., 15.28 deg.±0.2 deg., 17.05 deg.±0.2 deg., 17.93 deg.±0.2 deg., 23.51 deg.±0.2 deg. and 30.48 deg.±0.2 deg., and a melting point at 270 deg.C±1 deg.C.
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