摘要 |
PROBLEM TO BE SOLVED: To obtain a new futalosine capable of selectively inhibiting the proliferation of uterine cervix carcinoma cells infected with human papilloma virus and recognized to express its genes. SOLUTION: A compound of formula I (R<1> is H, methyl, wherein R<1> is H in futalosine, and R<1> is methyl in 6-O-methylfutalosine). The futalosine of formula II in the compound of formula I has the following physicochemical natures. Nature: slightly yellow powder; molecular formula: C19 H18 N4 O7 ; molecular weight: 414; specific rotation: [α]<24> D=+1.57 deg. (C 0.40, MeOH); mass spectrometry: FAB-MS (m/z), 413(M-H)<-> ; solubility: soluble in water, dimethyl sulfoxide; slightly soluble in methanol, acetone, chloroform, hexane; IR absorption spectrum (KBr tablet): 3200, 1700, 1605, 1560, 1395cm<-1> . The compound of formula II is obtained e.g. by aerobically culturing a fungus (FERM P-15887) belonging to the genus Streptomyces and producing the futalosine of formula II, and subsequently collecting the futalosine of formula II from the culture product. |