发明名称 |
recombinant poxviruses with foreign DNA in essential regions |
摘要 |
Defective poxviruses that lack a function imparted by an essential region of its parental poxvirus are provided for protein production and vaccination. A DNA polynucleotide encoding a protein is inserted into the defective poxvirus and placed under transcriptional control of a promoter. The defective poxvirus is viable when the lost function of the essential region is complemented by a host cell, transgenic animal or helper virus.
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申请公布号 |
US5766882(A) |
申请公布日期 |
1998.06.16 |
申请号 |
US19960616133 |
申请日期 |
1996.03.14 |
申请人 |
IMMUNO AKTIENGESELLSCHAFT |
发明人 |
FALKNER, FALKO-GUENTER;HOLZER, GEORG;DORNER, FRIEDRICH |
分类号 |
A01K67/027;A61K39/00;C07K14/07;C07K14/16;C12N5/10;C12N7/00;C12N7/01;C12N15/09;C12N15/39;C12N15/863;C12R1/92;(IPC1-7):C12N5/00;C12N15/00;C12P21/06 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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